The problem is the construction going on along Brookshire Boulevard near Mount Holly-Huntersville Road.
It was the second crash involving an overturned tractor-trailer on a busy Charlotte highway on Monday.
A tanker truck overturned on the ramp from I-77 South to Westinghouse Boulevard on Monday morning.
The section of Central Avenue connecting the Midtown and Plaza Midwood neighborhoods will be partially closed for months.
A section of Central Avenue will be reduced to one lane in both directions beginning Monday, Nov. 27.
The wreck happened around 4:50 a.m. along I-85 South at Mile Marker 69.