The State Highway Patrol is investigating the crash that happened just before midnight Monday.
Officials said the semi truck, carrying tons of produce lost control after the crash, and clipped a power pole before overturning.
Both drivers were pinned in their vehicles until emergency crews could arrive.
Power workers had to replace the downed pole, which took out electricity to neighborhoods.
Eastbound 74 was reduced to one open lane, westbound was blocked off while Troopers tried to put the pieces of the accident scene together.