In 2006, David Crespi stabbed his 5-year-old twin daughters to death in their Matthews home.
At the time, he was on a cocktail of prescription drugs including an anti-depressant, anxiety medication and sleep aids. He is currently serving two life sentences after pleading guilty to murder.
Two years before the Crespi murders, Canadian David Carmichael strangled his 11-year-old son with his own hands.
At the time, he says he was taking an anti-depressant. He is a now a free man, found not criminally responsible for the death of his son.
According to a 2013 study by researchers at the Mayo Clinic, more than one in ten Americans is prescribed an anti-depressant.
The Centers for Disease Control finds women are two and a half times more likely than men to take anti-depressants. The drugs can help control the symptoms of depression, but they also come with risks.
WBTV News Anchor Maureen O'Boyle sat down with David Crespi's wife, Kim, and with David Carmichael.
Tuesday night at 11, you'll hear their stories, how the two cases had such different outcomes, and learn what you need to know if you or someone you love is taking one of these powerful prescription drugs.